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Melittin treatment (0.1 mg/kg) lowered myocardial cell death, lowered Bax and caspase-3 expression, and increased Bcl-2

10.18388/abp.2000_3963 103 PanT.ChenY.ZhuangY.YangF.XuY.TaoJ.et al (2019)

It has been one of the most extensively studied copper peptides in dermatological and wound biology research, with over 100 published studies examining its effects on extracellular matrix remodeling, collagen synthesis, and tissue signaling

The Journal of Clinical Endocrinology & Metabolism, 75 (2), 530-535

In fact, transplanting senescent cells into mice knee joint has been found to induce an osteoarthritis-like change (Xu et al., 2017)